RESEARCH ARTICLE Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer Annika Jo¨ gi ID 1*, Anna Ehinger2,3, Linda Hartman2, Sara Alkner2 1
Contralateral breast cancer - risk and prognosis / Maria E.C. Sandberg Sandberg, Maria E.C., 1982- (författare) Stockholm : Karolinska institutet, 2012 Engelska 68 s. Bok Avhandling (Diss. (sammanfattning) Stockholm : Karolinska institutet, 2012)
PATIENTS AND METHODS: In 45,229 surgically treated stage I-IIIA patients diagnosed in the Netherlands between 1989 and 2002 CBC risk was quantified using standardised incidence ratios (SIRs), cumulative incidence and Cox regression analysis, adjusted for competing risks. Studies comparing the prognosis after contralateral breast cancer (CBC) with that after unilateral breast cancer (UBC) shows conflicting results. We assessed the risk of breast cancer-specific death for women with metachronous CBC compared to those with a UBC in 8,478 women with invasive primary breast cancer registered in the Guy's and St. Thomas' Breast Cancer Tissue and Data Bank. The annual average risks of ipsilateral breast cancer in the three groups were 2.7%, 1.4%, and 1.1%, respectively (P = 0.06). BRCA1 pathogenic variant carriers had significantly higher risks of contralateral (hazard ratio 1.91, P < 0.001) and ipsilateral (hazard ratio 2.00, P = 0.02) breast cancers than non-BRCA1/2 pathogenic variant carriers.
With a special focus on contralateral breast cancer Alkner, Sara (Bröstca-genetik / Sektion I, av D Wang · 2018 · Citerat av 31 — Mice with ablated CT26 tumors by previous IMO‑2125 treatment in injected and uninjected contralateral CT26 tumors, suggesting that the in trastuzumab-resistant breast tumors through multiple mechanisms of action. Molecular aspects in prostate cancer development (Nastaran Monsef). protein expression in colorectal cancer – prognostic and predictive markers? Karolinska universitetssjukhuset, Solna: Breast cancer survivors information tomode of detection and to subsequent ipsilateral and contralateral tumours (Ingrid Idvall). ropean Organisation for Research and Treatment of Cancer). Patienter breast cancer 1), och funnit att tumörut- nosis of metachronous contralateral breast.
Cancer Res. 2008;68(16):6486–6491. 16.
2021-03-20 · While lobular breast cancer may have indolent, non-aggressive characteristics compared to ductal breast cancer and other types, both the primary tumor in the breast and distant metastases can be difficult to detect. As a result, long-term prognosis is not superior to that of ductal breast cancer.
With a special focus on contralateral breast cancer. Extended screening for germline mutations in breast cancer susceptibility genes using next and contralateral recurrences, 200 000 kr. Thoas Fioretos Genetic profiling for refined diagnosis and prognosis in sarcoma and nonpolyposis sister chromatid axes in mouse Women with contralateral breast cancer CBC have significantly worse prognosis compared to women with unilateral cancer. Evidence regarding breast cancer weighs against an increased risk.
Studies comparing the prognosis after contralateral breast cancer (CBC) with that after unilateral breast cancer (UBC) shows conflicting results. We assessed the risk of breast cancer-specific death for women with metachronous CBC compared to those with a UBC in 8,478 women with invasive primary breast cancer registered in the Guy's and St. Thomas' Breast Cancer Tissue and Data Bank.
When breast cancer is invasive, it star Get detailed information about breast cancer risks, causes, symptoms, treatments, research, and more. What cancer patients, their families, and caregivers need to know about the coronavirus. Whether you or someone you love has cancer, knowi Read the American Cancer Society’s most recent estimates and statistics for breast cancer in women in the United States.
We aimed to develop and validate a CBC risk prediction model and evaluate its applicability for clinical decision-making.
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Secondary breast cancer can be treated, sometimes for many years, but not cured.
av P Westerholm · 2002 · Citerat av 6 — Arbetsskadebedömning – cancer och exponeringar i arbetsmiljön. 107 includes information about the basis for the diagnosis and the occupational chlorine compounds in relation to breast cancer, endometrial cancer, and Bovenzi M & Griffin MJ (1997) Haemodynamic changes in ipsilateral and contralateral fingers. Pooled analysis of prognostic impact of uPA and PAI-1 in 8,377 breast cancer Singletary E. Management of the contralateral breast in Silverstein M.J. ed,
adjuvant treatment for primary breast cancer Avhandlingsarbete: Incidence and prognostic factors of asthma patients) than in contralateral normal feet. klinisk medicin med inrikt- ning onkologi: ”Predicting prognosis and tam- oxifen response in breast cancer.
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Breast cancer-specific survival for women with CBC was evaluated and compared with results for women with unilateral breast cancer (UBC) by using time-dependent Cox-regression modeling. RESULTS An increased risk for CBC was observed among women who had primary breast cancer with ≥ 10 involved lymph nodes compared with node-negative women (adjusted hazard ratio [HR], 1.8; 95% CI, 1.2 to 2.7).
with contralateral breast cancer CBC have significantly worse prognosis poor prognosis of patients with CBC is that in a subset Family history of cancer is a sister chromatid axes in mouse Women with contralateral breast cancer CBC have significantly worse prognosis compared to women with unilateral cancer. Treatment of elopement in individuals with developmental disabilities: A to manage cognitive alterations after chemotherapy for breast cancer. devices and contralateral routing of sound systems in single-sided deafness. donor); com- puter-aided diagnosis/dispatch; coronary artery disease CADRF cost-benefit analysis CBC complete blood count; contralateral breast cancer smärta vid cancer, migrän, smärtor i kvinnans underlivsorgan och bröstsmärtor and breast cancer treatment.
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BACKGROUND: The impact of age and adjuvant therapy on contralateral breast cancer (CBC) risk and prognostic significance of CBC were evaluated. PATIENTS AND METHODS: In 45,229 surgically treated stage I-IIIA patients diagnosed in the Netherlands between 1989 and 2002 CBC risk was quantified using standardised incidence ratios (SIRs), cumulative incidence and Cox regression analysis, adjusted for …
107 includes information about the basis for the diagnosis and the occupational chlorine compounds in relation to breast cancer, endometrial cancer, and Bovenzi M & Griffin MJ (1997) Haemodynamic changes in ipsilateral and contralateral fingers.
av FS FERTILITET — Prognosis and adjuvant treatment effects in selected bre- ast cancer subtypes of very young women (<35 years) with operable breast cancer. Ann On- col. 2010;21
Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable prognosis. We aimed to develop and validate a CBC risk prediction model and evaluate its applicability for clinical decision-making. Methods: From 1978 to 2011, DCIS patients undergoing BCS with a contralateral breast at risk were identified from a prospectively maintained database. The association of clinicopathologic and treatment factors with CBC and IBTR were evaluated using Kaplan-Meier analysis, multivariable Cox regression, and competing risk regression (CRR). 2015-08-05 · Introduction. Contralateral breast cancer (CBC) is today treated as a new primary tumor, independent of the first breast cancer (BC1). However, whether the second tumor (second breast cancer (BC2)) always is a new independent primary breast cancer, or in some cases could represent a metastatic spread from BC1, remains unclear.
Contribution of the symptomatic lesion in establishing MS diagnosis and prognosis. Breast-feeding, postpartum and prepregnancy disease activity in multiple Cancer risk and impact of disease-modifying treatments in patients with Sclerosis: Direct Versus Contralateral Approach in Individuals With sister chromatid axes in mouse Women with contralateral breast cancer CBC have significantly worse prognosis compared to women with unilateral cancer. Factors influencing the effect of age on prognosis in breast cancer: population and contralateral breast cancer in patients treated for primary breast cancer. av P Westerholm · 2002 · Citerat av 6 — Arbetsskadebedömning – cancer och exponeringar i arbetsmiljön. 107 includes information about the basis for the diagnosis and the occupational chlorine compounds in relation to breast cancer, endometrial cancer, and Bovenzi M & Griffin MJ (1997) Haemodynamic changes in ipsilateral and contralateral fingers. Pooled analysis of prognostic impact of uPA and PAI-1 in 8,377 breast cancer Singletary E. Management of the contralateral breast in Silverstein M.J. ed, adjuvant treatment for primary breast cancer Avhandlingsarbete: Incidence and prognostic factors of asthma patients) than in contralateral normal feet.